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| 1959 SCHEDULEOverall 5-5Home 3-2Away 2-3 |
| Date | Opponent / Event | Location | Time / Result | Media | |
| Sat., Sep. 26 | vs. North Carolina |
Notre Dame, Ind. | W, 28-8 | More | |
| Sat., Oct. 3 | at Purdue |
West Lafayette, Ind. | L, 28-7 | More | |
| Sat., Oct. 10 | at California |
Berkeley, Calif. | W, 28-6 | More | |
| Sat., Oct. 17 | at Michigan State |
East Lansing, Mich. | L, 19-0 | TV: NBC | More |
| Sat., Oct. 24 | vs. Northwestern |
Notre Dame, Ind. | L, 30-24 | More | |
| Sat., Oct. 31 | vs. Navy |
Notre Dame, Ind. | W, 25-22 | More | |
| Sat., Nov. 7 | vs. Georgia Tech |
Notre Dame, Ind. | L, 14-10 | More | |
| Sat., Nov. 14 | at Pittsburgh |
Pittsburgh, Pa. | L, 28-13 | TV: ABC (Regional) | More |
| Sat., Nov. 21 | at Iowa |
Iowa City, Iowa | W, 20-19 | More | |
| Sat., Nov. 28 | vs. USC |
Notre Dame, Ind. | W, 16-6 | More | |
Schedule Key Home Event Away Event