Series Breakdown: Notre Dame vs. 2012 Opponents
| Opponents | Series Start | Series Record | Streak | Last Meeting |
| Navy | 1927 | Notre Dame leads 73-12-1 | W2 | W, 50-10 (09/01/12) |
| Purdue | 1896 | Notre Dame leads 56-26-2 | W5 | W, 20-17 (9/8/12) |
| Michigan State | 1897 | Notre Dame leads 47-28-1 | W2 | W, 20-3 (9/15/12) |
| Michigan | 1887 | Michigan leads 23-16-1 | W1 | W, 13-6 (9/22/12) |
| Miami | 1955 | Notre Dame leads 17-7-1 | W3 | W, 41-3 (10/6/12) |
| Stanford | 1925 | Notre Dame leads 18-9 | W1 | W, 20-13 (OT) (10/13/12) |
| BYU | 1992 | Notre Dame leads 4-2 | W1 | W, 49-23 (10/22/05) |
| Oklahoma | 1952 | Notre Dame leads 8-1 | W6 | W, 34-30 (10/2/99) |
| Pittsburgh | 1909 | Notre Dame leads 46-20-1 | W2 | W, 15-12 (9/24/11) |
| Boston College | 1975 | Notre Dame leads 12-9 | W3 | W, 16-14 (11/19/11) |
| Wake Forest | 2011 | Notre Dame leads 1-0 | W1 | W, 24-17 (11/5/11) |
| USC | 1926 | Notre Dame leads 43-35-5 | L1 | L, 31-17 (10/22/11) |